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ANTIOXIDANT AND DETOXIFICANT DEFENSE SYSTEMS 1. Role of GSH as a protective agent • GSH as a substrate in thiol disulfide exchange reactions (GR, GPx, Prx) • GSH as a substrate in conjugation reactions (GSTs) • De novo synthesis of GSH and regulation • GSH content in response to environmental factors 2. Glutathione Transferases Families 2.1 Cytosolic GSTs: Classes and catalyzed reactions • Detoxification through mercapturic acid pathway • Bioactivation of xenobiotics • Detoxification of products of oxidative stress • Degradation of aromatic aminoacids • Polymorphisms in cytosolic GSTs 2.2 GST and Eicosanoids: Synthesis and Inactivation 2.3 Modulation of signalling pathways by GSTs 2.4 Substrate preferences and tissue distribution 2.5 Mitochondrial GST and evolution of GSTs fold 2.6 MAPEG enzymes 2.7 Knock out of GST genes 2.8 Regulation of GSTs
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